It is a nitrogenous waste and a product of ammonia.
Urea is less toxic and less soluble.
Terrestrial animals eliminate urea as a waste product. Ex.- Amphibians, Mammals.
UREA SYNTHESIS
Urea synthesis occurs in liver, the process of conversion of toxic ammonia into less toxic urea is called urea cycle (or) ornithene cycle or Krebs’s cycle.
Ammonia is produced by deamination of amino acids combines with by using two molecules of
ATP to form carbamoyl phosphate.
Carbomoyl group is transferred to ornithene to form citrulline and
Citrulline combines with another amino acid (asparatate) by using ATP to form arginino succinate and it splits into arginine and fumarate.
Arginine regenerated again and again in the cycle and urea is taken to kidney where it is converted into urine.
URIC ACID
It is a nitrogenous waste and a product of purines and pyramidines.
It is least toxic and least soluble in water and formation occurs in it is the only nitrogenous waste eliminated in semi solid form along with fecus.